Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.
نویسندگان
چکیده
Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 72 1 شماره
صفحات -
تاریخ انتشار 1975